An ever increasingly important need in the age of information technology is to make computers, robots, and other machines to interact intelligently with humans, with the physical world, with each other, and to enable effective virtual interactions to augment, extend, and even substitute interactions in the real physical world. At the Intelligent, Multimedia, and Interactive Systems Lab, research is focused on investigating novel technologies and methodologies to enable and support such intelligent interactions for effective use of information of various forms and for optimal performance of tasks involved.